Submitted by: Noushin Moshgabadi
Chemotherapy can have side effects in normal cells. Tumours can also develop resistance to therapeutic treatment. The aim of my project is to identify conditions that better sensitize cancer cells to chemotherapy.
Cancer cells carry somatic mutations that genotypically distinguish them from noncancerous cells. We take advantage of the presence of the somatic mutation in cancer cells in combination to DNA repair enzyme inhibitor and chemotherapy agents. The inhibition of DNA repair enzyme inhibits the repair of somatic mutation and also the damage that was induced by chemotherapy agents in cancer cells. Therefore, only cancer cells will be eliminated.